Bioprinted natural polysaccharides with tunable properties to stimulate skin wound healing and tissue regeneration
- Supervisor: Amin Shavandi
- Research center: BioMatter unit Biomass Transformation Lab
- Research start date: 01.11.2020
Description
Polysaccharides have been considered to be promising wound healing that could be accepted as important candidates for the development of effective and non-toxic medicines with stronger activities in vitro and in vivo. Scaffolds synthesized from bioactive and biocompatible polymers such as microbial (exo) polysaccharides are of great importance in this field. The emergence of tissue-engineered skin alternatives has revolutionized the therapeutic potential for severe wounds and ulcers.
The overall objective of my project is to develop new bioprinted scaffolds based on natural polysaccharides with tunable properties to stimulate skin wound healing and tissue regeneration.
Biography
I’ve got my B.Sc. degree of Clinical Laboratory in Paramedicine Faculty of Shahid Beheshti University of Medical Sciences, Tehran, Iran and my M.Sc. degree of Microbial Biotechnology form Faculty of Science, Shahed University, Tehran, Iran. Also, I graduated in Ph.D. of Pharmaceutical Biotechnology in 2014 from Tabriz University of Medical Sciences (ranked among top universities in Iran) under supervision of Prof. Hejazi and Prof. Nazemieh. During the Ph.D thesis, I worked on isolation, biochemical and molecular identification of marine haloarchaea from Urmia Lack and characterization of carotenoid pigments produced by thesis isolates. Also I worked on optimization of carotenoid and biomass production using Response Surface Methodology method.
After Ph.D., I was working as Faculty member of Guilan University of Medical Sciences, Department of Medical biotechnology. My main projects were exopolysaccharide production by microorganisms (haloarchaea and yeasts) and applications of these biopolymers in tissue engineering, waste treatment (by removing of heavy metals) and so on.
My skills falls into two categories 1. IT skills: End Note, Word Office, PowerPoint Office, Statistical softwares (SPSS, Graphpad Prism), Minitab, and Bioinformatics softwares like: MEGA, DNASIS MAX, AlleleID. 2. Technical Skills: Bacterial culture and handling, bacterial identification and characterization, DNA and RNA extraction, PCR, Real-time PCR, Electrophoresis, gene cloning, UV-Visible Spectroscopy, TLC, HPLC, LC-MS.
Publications
1. Abazari, M.F., et al., Recent advances in cellulose-based structures as the wound-healing biomaterials: A clinically oriented review. Applied Sciences (Switzerland), 2021. 11(17).
2. Ahmadi, N.A. and M. Hamidi, A retrospective analysis of human cystic echinococcosis in Hamedan province, an endemic region of Iran. Annals of Tropical Medicine and Parasitology, 2008. 102(7): p. 603-609.
3. Ahmadi, N.A. and M. Hamidi, Unusual localizations of human hydatid disease in Hamedan province, west of Iran. Helminthologia, 2010. 47(2): p. 94-98.
4. Azizi, M., et al., Microbiological pattern and antibiotic susceptibility of agents isolated from Nosocomial infections, staff and equipment of surgery section and ICU of imam khomaini hospital, Ilam, Iran. Journal of Pure and Applied Microbiology, 2014. 8(2): p. 1059-1064.
5. Bashiri, H., et al., Dual preconditioning: A novel strategy to withstand mesenchymal stem cells against harsh microenvironments. Advanced Pharmaceutical Bulletin, 2018. 8(3): p. 465-470.
6. Hamidi, M., et al., Optimization of total carotenoid production by Halorubrum Sp. TBZ126 using response surface methodology. Journal of Microbial and Biochemical Technology, 2014. 6(5): p. 286-294.
7. Hamidi, M., et al., Production, characterization and biological activities of exopolysaccharides from a new cold-adapted yeast: Rhodotorula mucilaginosa sp. GUMS16. International Journal of Biological Macromolecules, 2020. 151: p. 268-277.
8. Hamidi, M., M. Hajilooei, and A. Bazmani, Association of transforming growth factor-β1 gene polymorphism with visceral leishmaniasis in an iranian population. Shiraz E Medical Journal, 2013. 14(2).
9. Hamidi, M., et al., Halorubrum Sp. TBZ112, an extremely halophilic carotenoid- producing archaeon isolated from Urmia Lake. Pharmaceutical Sciences, 2017. 23(2): p. 150-158.
10. Hamidi, M., et al., Characterization of a new exopolysaccharide produced by Halorubrum sp. TBZ112 and evaluation of its anti-proliferative effect on gastric cancer cells. 3 Biotech, 2019. 9(1).
11. Hamidi, M., et al., Study on antibacterial activity of newly synthesized derivatives of pyranopyrazole, pyrazolo[1,2-b]phtalazine and bis-pyrazole. Acta Microbiologica Hellenica, 2019. 64(1): p. 33-40.
12. Hamidi, M., et al., Marine bacteria versus microalgae: Who is the best for biotechnological production of bioactive compounds with antioxidant properties and other biological applications? Marine Drugs, 2020. 18(1).
13. Hamidi, M., et al., Determining the relationship between Epstein Barr virus and nasopharyngeal carcinoma by polymerase chain reaction. Journal of Mazandaran University of Medical Sciences, 2013. 22(SUPPL. 1): p. 51-60.
14. Hamidi, M., et al., The effects of essential oil of Lavandula angustifolia on sperm parameters quality and reproductive hormones in rats exposed to cadmium. Journal of Reports in Pharmaceutical Sciences, 2015. 4(2): p. 121-128.
15. Hivechi, A., et al., Synthesis and characterization of exopolysaccharide encapsulated PCL/gelatin skin substitute for full‐thickness wound regeneration. Polymers, 2021. 13(6).
16. Khanaki, K., M. Abedinzade, and M. Hamidi, The effects of urtica dioica and lamium album extracts on the expression level of cyclooxygenase-2 and caspase-3 in the liver and kidney of streptozotocin-induced diabetic rats. Pharmaceutical Sciences, 2019. 25(1): p. 37-43.
17. Naziri, D., et al., Analysis of carotenoid production by Halorubrum sp. TBZ126; an extremely halophilic archeon from Urmia Lake. Advanced Pharmaceutical Bulletin, 2014. 4(1): p. 61-67.
18. Okoro, O.V., et al., Optimization of exopolysaccharide (Eps) production by rhodotorula mucilaginosa sp. gums16. ChemEngineering, 2021. 5(3).
19. Safarzadeh Kozani, P., et al., Polysaccharide-based hydrogels: properties, advantages, challenges, and optimization methods for applications in regenerative medicine. International Journal of Polymeric Materials and Polymeric Biomaterials, 2021.
20. Seveiri, R.M., et al., Characterization and prospective applications of the exopolysaccharides produced by rhodosporidium babjevae. Advanced Pharmaceutical Bulletin, 2020. 10(2): p. 254-263.
21. Sheikhi, N., et al., Evaluating the clinical application of nested PCR in the diagnosis offungal infections. New Zealand Journal of Medical Laboratory Science, 2020. 74(2): p. 115-118.
22. Simorgh, S., et al., Human olfactory mucosa stem cells delivery using a collagen hydrogel: As a potential candidate for bone tissue engineering. Materials, 2021. 14(14).
23. Yektakooshali, M.H., et al., Prevalence of group B streptococcus colonization in iranian pregnant women: A systematic review and meta-analysis. International Journal of Reproductive BioMedicine, 2018. 16(12): p. 731-744.
24. Zolfigol, M.A., et al., Alum as a catalyst for the synthesis of bispyrazole derivatives. Applied Sciences (Switzerland), 2016. 6(1): p. 1-9.
25. Zolfigol, M.A., et al., Synthesis of Indolo[3,2-b]carbazoles via an Anomeric-Based Oxidation Process: A Combined Experimental and Computational Strategy. Journal of Heterocyclic Chemistry, 2018. 55(4): p. 1061-1068.